Since liquid crystal molecules order with one another, they respond to the system geometry. Geometrical constraints can generate patterns and defects – localized, “melted” areas of disorder that can lower the overall distortion in the system. I will present recent work where defects in synthetic liquid crystals are controlled using microfluidics to generate liquid crystal double emulsions – confining the liquid crystal into spherical shells. Defect types and their configurations are tunable with the system geometry and by varying the molecular alignment. These tools can be applied to pattern nanoparticles at the liquid crystal interface. I will end by discussing future research directions, where geometrical confinement and controlled alignment can be leveraged to design bio-inspired materials.